Pathogen Lymphocystis disease virus
Taxonomy Iridoviridae
Hosts Japanese flounder (Paralichthys olivaceus), Red sea bream (Pagrus major), Yellowtail (Seriola quinqueradiata), Japanese sea bass (Lateolabrax japonicus), etc.
Infection site Skin, fin
Clinical sign Numerous tumor-like lesions are found on the skin or fin. Mass of lymphocystis cells are observed as white mass in yellowtail, while black spots in yellowtail.
Virology DNA virus of 130-260 nm in size. It infects the dermal fibroblasts, producing hypertrophied cells that are visible (100-500ƒÊm)to the naked eye (Noga, 1996).
Pathology While it causes only low mortality, the infected fish loses the commercial value. In advanced stages, as the lymphocysts rupture, numerous inflammatory cells surround the lesions (Noga, 1996).
Health hazard Harmless for human health.
Diagnosis Presumptively, check the external sign of lymphocystis cells. For confirmation, the virus should be isolated and CPE is examined, following to PCR test..
Other information Selective breeding of resistant strain of Japanese flounder has been successful and almost in practical stage.
References

Noga, E. J. (1995): Fish Disease: diagnosis and treatment. Mosby, Missouri, pp. 367.

(Photo by T. Awakura)

Fig. 1. Japanese flounder showing the lymphocystis disease.